Most goals as substitute in one Premier League season, 2000-

2011/2012
1. Victor Anichebe [Everton] - 5 goals
2. Jermain Defoe [Tottenham] - 4 goals
2. Edin Dzeko [Man. City] - 4 goals

2010/2011
1. Javier "Chicharito" Hernandez [Man. United] - 5 goals
2. Ivan Klasnic [Bolton] - 4 goals
2. Sylvan Ebanks-Blake [Wolverhampton] - 4 goals
2. Roman Pavluychenko [Tottenham] - 4 goals
2. Salomon Kalou [Chelsea] - 4 goals

2009/2010
1. Kevin Phillips [Birmingham] - 4 goals
1. Steven Thompson [Burnley] - 4 goals
1. Jason Roberts [Blackburn] - 4 goals

2008/2009
1. Darren Bent [Tottenham] - 4 goals
2. Daniel Sturride [Man. City] - 3 goals
2. Erik Nevland [Fulham] - 3 goals
2. Mido [Middlesbrough / Wigan] - 3 goals
2. John Carew [Aston Villa] - 3 goals
2. Nicklas Bendtner [Arsenal] - 3 goals

2007/2008
1. Marlon Harewood [Aston Villa] - 5 goals
2. Emmanuel Adebayor [Arsenal] - 4 goals
3. Louis Saha [Man. Utd], Matt Derbyshire [Blackburn], Darren Bent [Tottenham], Andy Johnson [Everton], Jermain Defoe [Tottenham], Michael Chopra [Sunderland] - 3 goals

2006/2007
1. Matt Derbyshire [Blackburn] - 4 goals
2. Bobby Zamora [West Ham] - 3 goals
2. Salomon Kalou [Chelsea] - 3 goals
2. Nwankwo Kanu [Portsmouth] - 3 goals

2005/2006
1. Robin van Persie [Arsenal] - 4 goals
1. Shefki Kuqi [Blackburn] - 4 goals
1. Collins John [Fulham] - 4 goals

2004/2005
1. Robert Earnshaw [West Bromwich] - 5 goals
2. Mateja Kezman [Chelsea] - 4 goals
2. Joe Cole [Chelsea] - 4 goals
2. Duncan Ferguson [Everton] - 4 goals
2. Robbie Keane [Tottenham] - 4 goals

2003/2004
1. Hernan Crespo [Chelsea] - 4 goals
1. Jimmy Floyd Hasselbaink [Chelsea] - 4 goals
1. Szilard Nemeth [Middlesbrough] - 4 goals

2002/2003
1. Geoff Horsfield [Birmingham] - 4 goals
2. Scott Dobie [West Bromwich] - 3 goals
2. Michael Ricketts [Bolton / Middlesbrough] - 3 goals
2. Massimo Maccarone [Middlesbrough] - 3 goals
2. Jermain Defoe [West Ham] - 3 goals

2001/2002
1. Jermain Defoe [West Ham] - 6 goals
2. Mikael Forssell [Chelsea] - 4 goals
3. Vladimir Smicer [Liverpool], Sylvain Wiltord [Arsenal], Dennis Bergkamp [Arsenal] - 3 goals

2000/2001: 
1. Julian Joachim [Aston Villa] - 4 goals
2. Arnar Gunnlaugsson [Leicester] - 3 goals
2. Robbie Keane [Leeds] - 3 goals